An inherited disorder characterized by abnormalities of the skull, face, hands, and feet. It begins with premature closure of some sutures of the skull (craniosynostosis) and results in a tall peaked head, shallow eye sockets, and underdeveloped cheekbones. With acro- cephalosyndactyly, fingers and toes are fused (syn- dactyly), and the thumbs and big toes have broad ends. Acrocephalosyndactyly is an autosomal domi- nant trait that affects boys and girls. A parent can transmit the gene for the disorder, or it can occur due to a new mutation. Surgery is often useful to correct the abnormalities of the skull, face, hands, and feet.