These issues are extremely ________ and any knee jerk reaction will ultimately result in a loss of ________ for all shareholders

Nuance means a subtle difference in colour, meaning, tone, etc a shade or graduation
knee jerk reaction impulsive reaction which might not be always appropriate because here decesion/reactions are taken without much thinking .
Since the issue is nuanced so it has to be studied carefully and given proper time to be analysed otherwise it would result in a loss of opportunity. All other choices are irrevelent.