Topic: Adverse Drug Effect
Subject: Medicine
During the morning rounds, a second year resident presents a patient as a 58-year-old female who suffers from rigidity and tremors. She has been diagnosed with a neurodegenerative disease involving the depigmentation of substantia nigra and loss of dopaminergic input to basal ganglia. Identify the medication that would worsen rather than improve this patient's condition?

Correct Answer : C.

Answer: C - Chlorpromazine is a phenothiazide derivative effective in the treatment of positive symptoms of schizophrenia. One of the side effects of phenothiazide derivatives is induction of pseudoparkinsonism. Since the patient is already suffering from the symptoms of parkinsons disease, administration of chlorpromazine would further worsen the condition. All remaining options are Antiparkinson medications and could be used in the management of this patient.