Topic: Alzheimer's Disease Subject: Medicine Which one of the following is most predictive of the progression from mild cognitive impairment to frank Alzheimers dementia?
A. Self-reported memory deficits
B. Memory deficits reported by a family member
C. A normal MRI scan of the brain
D. The absence of the apolipoprotein E4 allele
Correct Answer : B.
Informant-reported deficits in memory and cognitive function correlate best with progression from mild cognitive impairment to Alzheimers dementia. Selfreported deficits confer a much smaller likelihood of progression. Hippocampal atrophy and the presence of the E4 allele also correlate with progression.