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Topic: Alzheimer's Disease
Subject: Medicine
Which one of the following is most predictive of the progression from mild cognitive impairment to frank Alzheimers dementia?

A. Self-reported memory deficits

B. Memory deficits reported by a family member

C. A normal MRI scan of the brain

D. The absence of the apolipoprotein E4 allele

Correct Answer : B.


Informant-reported deficits in memory and cognitive function correlate best with progression from mild cognitive impairment to Alzheimers dementia. Selfreported deficits confer a much smaller likelihood of progression. Hippocampal atrophy and the presence of the E4 allele also correlate with progression.

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