nodular or sessile lesions usually invade muscle
papillary bladder tumors are typical of low stage and grade
carcinoma in situ appears as a flat, velvety patch
sarcomas commonly invade bladder base and ureteral orifices causing obstructions
D. sarcomas commonly invade bladder base and ureteral orifices causing obstructions
well-differentiated tumor with broad-based invasive font
marked atypia distributed on wide areas of superficial urothelium
atypia is present
no atypia but marked degenerative epithelial changes
continue the procedure as perforations at this site do no harm
abort the procedure and leave a urethral catheter
convert tumor removal to open method and repair the defect
perform abdominal exploration and manage accordingly
ascending urethrography
voiding cystourethrography
MRI
IVU
patients with carcinoma in situ
patients with completely resected solitary tumor
patients with preserved kidney and liver functions after 2 courses of BCG
patients with leiomyosarcoma
obstructive LUTS are common presentations and occur in association with carcinoma in situ
might present as perineal abscesses and fistulae
could be asymptomatic
venereal diseases increase the risk of urethral cancers
cisplatin
BCG
mitomycin C
5-fluorouracil
sensitivity to chemotherapy and age at presentation
anatomic location and extent of the tumor
histologic type of the tumor and sensitivity to radiotherapy
tumors stage and grade
history of pulmonary TB
total incontinence
immunosuppression
impaired renal function
0.6 - 2%
2 - 6%
6 - 10%
12 - 16%
the anterior urethra drains into the inguinal and pelvic nodes
the posterior urethra drains into the pelvic nodes
the proximal two-thirds drain into the external and internal iliac nodes
the distal one-third drains into the obturator nodes
RB
cyclin A
HRAS
CD-44
radical cysto-prostatectomy
anterior pelvic exenteration
bilateral pelvic lymphadenectomy
creation of a urinary diversion
immediately before operation
immediately before incision and post-operative for 1 day
immediately before incision and post-operative for 15 days
immediately before incision and post-operative for 30 days
never
unlikely
likely
always
infiltrative proximal penile urethral carcinomas
infiltrative distal penile urethral carcinomas
recurrent proximal penile urethral carcinoma after laser resection
T3/N2/M0 at bulbar urethra
adenocarcinoma
transitional cell carcinoma
squamous cell carcinoma
basal cell carcinoma
rarely diagnosed at autopsy
the peak incidence occurs between ages 70 and 80
they occur twice as frequently in men as in women
none of the above
high specificity
high sensitivity
high reliability
strong validity
the standard treatment is transurethral resection
the prognosis for inverted papilloma is pathetic, with a recurrence rate of approximately 65%
the likelihood of synchronous urothelial carcinoma is 26%
has been shown to harbor p53 gene mutations
epirubicin
mitomycin c
BCG
none of the above
the lesion is solitary and no associated CIS
physically, a surgical margin of 2-cm can be obtained
the resected area should be far enough from ureteral orifices and the bladder neck
all of the following
obstructive uropathy
painless hematuria
pain radiating to the groin
locally advanced tumor
undergo cystectomy
try mitomycin c
take a second course of BCG
take a second course of BCG + quinolones
often of high-grade sarcomas
often associated with muscularis propria invasion
due to vesical polyps occluding ureteric orifices
should be resected but not diathermized
30%
40%
50%
60%
irritative bladder symptoms
obstructive bladder symptoms
palpable suprapubic mass on physical examination
painless profuse hematuria
2%
5%
70%
90%
40 - 55%
55 - 70%
70 - 85%
85 - 100%
transitional cell carcinoma
squamous cell carcinoma
adenocarcinoma
small cell carcinoma
bladder perforation
obturator nerve reflex
vesico-ureteral reflux
terrible bleeding