Urology Basic Science 1000+ MCQ with answer for ISRO Recruitment

1. What do the specialized cells, at the juxtaglomerular apparatus, produce?
A. erythropoietin
B. renin
C. angiotensin I
D. angiotensinogen
Answer : B

2. What is the most likely diagnosis of an erectile dysfunction patient with low plasma testosterone and high prolactin levels?
A. pituitary adenoma
B. adrenal adenoma
C. Kallmann syndrome
D. Klinefelter syndrome
Answer : A

3. Bacterial resistance to antibiotics may occur because of:
A. inherited chromosomal-mediated resistance
B. acquired chromosomal-mediated resistance
C. extrachromosomal-mediated resistance
D. all of the above
Answer : D

4. What increases blood volume and pressure in corpora cavernosa during erection is:
A. increase in sympathetic discharge
B. contraction of ischiocavernosa and bulbocavernosa muscles
C. increase arterial flow and closure of emissary veins
D. shunting of blood from the dorsal to the central cavernosal artery
Answer : C

5. Beside renal excretion of sodium, what does atrial natriuretic hormone cause?
A. constriction of renal afferent arterioles
B. renin inhibition
C. aldosterone stimulation
D. rise in systemic blood pressure
Answer : B

6. In males, which of the following structure(s) can NOT be palpated during digital rectal examination?
A. pelvic floor muscles
B. seminal vesicles
C. anterior surface of the sacrum
D. median lobe of the prostate
Answer : D

7. What is the nerve supply of the adrenal gland?
A. sympathetic to the medulla
B. parasympathetic to the medulla
C. sympathetic to the cortex
D. parasympathetic to the cortex
Answer : A

8. At what month of intra-uterine life do testes descend into the scrotum with the aid of the intra-abdominal pressure and the gubernacula?
A. sixth
B. seventh
C. eighth
D. ninth
Answer : B

9. Which artery(ies) supply(ies) the prostate?
A. middle rectal
B. inferior vesical
C. a & b
D. none of the above
Answer : C

10. What helps in treating Candida albicans cystitis is:
A. sodium bicarbonate
B. phyto soya
C. ascorbic acid
D. sol palmetto
Answer : A

11. Which organ contributes most to the seminal fluid volume?
A. testes
B. prostate
C. seminal vesicles
D. bulbourethral glands
Answer : C

12. What vessels are located in the prostate neurovascular bundle?
A. Watson plexus
B. capsular arteries and veins
C. inferior vesical and midrectal vessels
D. Santorini plexus
Answer : B

13. What is true regarding hematospermia?
A. should be investigated thoroughly like hematuria
B. is rarely associated with significant urologic pathology
C. carries a risk of infertility
D. mandates testicular biopsy
Answer : B

14. Regarding renal ectopia, usually, the adrenals:
A. are cross ectopic
B. are at their normal position
C. travel with the kidneys
D. undergo ischemic atrophy
Answer : B

15. The mature genitourinary system develops from all of the following embryonic sources, EXCEPT:
A. intermediate mesoderm
B. mesothelium of celomic cavity
C. endoderm of the urogenital sinus
D. somatic ectoderm
Answer : D

16. The epithelial component of the prostate consists of all of the following, EXCEPT:
A. basal cells
B. intermediate cells
C. tubulo-columnar cells
D. neuroendocrine cells
Answer : C

17. Which class of the following diuretics could cause erectile dysfunction?
A. loop diuretics
B. thiazide diuretics
C. potassium sparing diuretics
D. osmotic diuretics
Answer : B

18. What does make UTI more common in mid-aged females than in males?
A. short female urethra
B. pregnancy
C. vaginal colonization with enterobacteria
D. all the above
Answer : D

19. What is false concerning fosfomycin antibiotic?
A. has a limited cross-resistance with most common antibacterial agents
B. causes injection site reactions
C. is active against most uropathogens
D. is effective as a single-dose agent
Answer : B

20. What is the approximated bladder capacity of an 8 yrs. girl?
A. 150 ml
B. 200 ml
C. 250 ml
D. 300 ml
Answer : D

21. Which statement concerning urine pH is false?
A. influenced by food and medications
B. renal stones form at the extremes of pH range
C. reliable only when measured by 24 hr. urine collection
D. ranges from 4 7
Answer : C

22. Which statement explains the first event in the micturition reflex?
A. opening of internal bladder sphincter
B. fall in urethral pressure
C. rise in intravesical pressure
D. cessation of sphincter EMG activity
Answer : D

23. Which of the following does NOT affect serum creatinine?
A. gender
B. age
C. obstructing stone at left lower ureter
D. rhabdomyolysis
Answer : C

24. Which hormone measures testicular germ cell function best?
A. LH
B. FSH
C. HCG
D. none of the above
Answer : B

25. How many days does spermatogenesis take in the man?
A. 16
B. 32
C. 64
D. 90
Answer : C

26. At which condition is alpha-fetoprotein most frequently elevated?
A. infiltrating ductal carcinoma of the breast
B. seminoma
C. hepatocellular carcinoma
D. malignant melanoma
Answer : C

27. Which microbe causes red diaper syndrome?
A. Serratia marcescens
B. Streptococcus pyogenes
C. Clostridium difficile
D. Staphylococcus saprophyticus
Answer : A

28. What is the half-life of ?-HCG?
A. 5 7 days
B. 24 36 hours
C. 2 3 days
D. 12 24 hours
Answer : B

29. Which of the following contributes second to the seminal fluid by volume?
A. seminal vesicles
B. the prostate
C. testes
D. bulbourethral glands
Answer : B

30. At which week of gestation do the primordial germ cells migrate to form the genital ridges?
A. third
B. fourth
C. fifth
D. seventh
Answer : C

31. In utero, which hormone stimulates the development of Wolffian ducts?
A. estradiol
B. DHT
C. FSH
D. testosterone
Answer : D

32. What causes pure testicular feminization is:
A. over estrogen synthesis
B. defective end-organ androgen response
C. extra X chromosome (XXY)
D. failure of genital ridge regression
Answer : B

33. What is the best initial therapy for hyponatremic dehydration?
A. administration of hypertonic saline
B. administration of crystalloid
C. administration of normal saline
D. administration of ringer lactate
Answer : C

34. What is false concerning renal vasculature?
A. there are 4 surgical segments of the kidney, based on the segmental artery distribution
B. along the kidney convexity, there is an avascular plane
C. there are no collaterals between segmental arteries
D. in < 10%, the posterior branch is the first to branch off the renal artery
Answer : D

35. What are the first and second most common zones from where prostate cancers arise?
A. central then transitional
B. peripheral then transitional
C. peripheral then central
D. transitional then central
Answer : B

36. Which medicine(s) might enhance hypoprothrombinemic effect on oral anticoagulants?
A. allopurinol
B. aminoglycosides
C. cimetidine
D. all of the above
Answer : D

37. Which ?- adrenergic receptor subtype mediates smooth muscle contraction of the prostate?
A. ?1-A
B. ?2-A
C. ?1-B
D. ?2-B
Answer : A

38. What fascial layer(s) cover(s) the prostate?
A. Denonvilliers fascia
B. prostatic fascia
C. levator fascia
D. all of the above
Answer : D

39. Which organism is capable of proliferation in the urine and causing urethritis?
A. Ureaplasma urealyticum
B. Chlamydia trachomatis
C. E. coli
D. Neisseria gonorrhea
Answer : A

40. Where is Santorini plexus located?
A. at either side of the prostate
B. in the pubo-prostatic space
C. anterior to the seminal vesicles
D. posterior to the vaso-epididymal junction
Answer : B

41. What degrades semenogelin and determines the consistency of the seminal coagulum is:
A. spermine
B. acid phosphatase
C. PSA
D. semenoglobulin
Answer : C

42. All of the following conditions are related to obesity syndrome, EXCEPT:
A. super fertility
B. increase aromatization reaction
C. increase resistance to circulating insulin
D. sleep apnea
Answer : A

43. What is false concerning PSA molecule?
A. the free form of PSA exists in small proportions in the body, and found mainly in BPH and in the ejaculate
B. ?1- anti chymotrypsin binds to 3 epitopes of the PSA molecule to form a complexed PSA
C. ?2- macroglobulin binds to 5 epitopes of the PSA molecule to form a complexed PSA
D. the purified PSA molecule has a molecular weight of 90 kDa
Answer : D

44. What does apoptosis mean?
A. programmed cell death
B. new vascular formation
C. uninhibited neural stimulation
D. premature muscular contraction
Answer : A

46. During fluoroscopy, what is the main source of radiation hazards that urologists could be exposed to?
A. scattered radiation from the unleaded wall
B. scattered radiation from the patient
C. scattered radiation from the floor and ceiling
D. radiation from the primary beam
Answer : B

47. Which of the following does NOT increase in prostate cancer?
A. human kallikrein 2
B. pro-PSA
C. free PSA
D. complexed PSA
Answer : C

48. On tracing the IVU dye down, in a dilated ureter, the dilation stops at a level then continues as a normal calibre ureter. What could the pathology be?
A. lower ureteral stricture
B. ureteral valve
C. modified Lich-Gregoire ureteral reimplantation
D. residual dilation of hydroureter
Answer : B

49. Which part of the prostate is traversed by the ejaculatory duct:
A. central zone
B. peripheral zone
C. transitional zone
D. fibromuscular stroma
Answer : A

50. What is the narrowest part of the ureter?
A. uretero-pelvic junction
B. uretero-vesical junction
C. where ureters cross the pelvic brim
D. where ureters cross the common iliac bifurcation
Answer : B