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Topic: Alzheimer's Disease
Subject: Medicine
Which one of the following is associated with an increased risk of developing Alzheimers disease?

A. A positive homozygous genotype for apolipoprotein E4

B. Elevated serum aluminum

C. Elevated serum alpha-tocopherol

D. Decreased serum Beta-carotene

Correct Answer : A.


Recent genetic work has demonstrated a high risk for the development of Alzheimers disease in patients with the apolipoprotein E4 genotype. Other predictors of the disease have been elusive. Serum aluminum is not predictive, although higher than normal brain aluminum levels have been studied for many years. Eating a low-fiber diet has no known correlation, and serum levels of Beta-carotene and vitamin E are not useful for predicting the development of Alzheimers disease, although supplementation is considered helpful by some sources.

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