upper ureter
middle ureter
lower ureter
comparable
C. lower ureter
tumor stage
tumor grade
lymphovascular invasion
lymph node spread
radical cysto-prostatectomy
anterior pelvic exenteration
bilateral pelvic lymphadenectomy
creation of a urinary diversion
single intravesical chemotherapy
TURBT
intravesical BCG vaccine
multiple bladder biopsies
adenocarcinoma
transitional cell carcinoma
squamous cell carcinoma
basal cell carcinoma
adenocarcinoma
transitional cell carcinoma
squamous cell carcinoma
basal cell carcinoma
sensitivity to chemotherapy and age at presentation
anatomic location and extent of the tumor
histologic type of the tumor and sensitivity to radiotherapy
tumors stage and grade
never
unlikely
likely
always
mid prostate to the verumontanum at the 5 and 7 oclock positions
lateral margins of the prostate at the 10 and 2 oclock positions
entire area distal to the urethral crest
area between ejaculatory duct openings and prostatic utricle
rarely diagnosed at autopsy
the peak incidence occurs between ages 70 and 80
they occur twice as frequently in men as in women
none of the above
urine cytology
CT urography
cystoscopy
renal function tests
2%
5%
70%
90%
multifocality
high tumor grade and advanced stage
presence of CIS
all of the above
RB
cyclin A
HRAS
CD-44
bladder perforation
obturator nerve reflex
vesico-ureteral reflux
terrible bleeding
obstructive LUTS are common presentations and occur in association with carcinoma in situ
might present as perineal abscesses and fistulae
could be asymptomatic
venereal diseases increase the risk of urethral cancers
the lesion is solitary and no associated CIS
physically, a surgical margin of 2-cm can be obtained
the resected area should be far enough from ureteral orifices and the bladder neck
all of the following
30%
40%
50%
60%
40 - 55%
55 - 70%
70 - 85%
85 - 100%
adenocarcinoma
transitional cell carcinoma
squamous cell carcinoma
basal cell carcinoma
2 - 4%
4 - 6%
6 - 8%
8 - 10%
transitional cell carcinoma
squamous cell carcinoma
adenocarcinoma
small cell carcinoma
well-differentiated tumor with broad-based invasive font
marked atypia distributed on wide areas of superficial urothelium
atypia is present
no atypia but marked degenerative epithelial changes
10%
20%
30%
40%
leiomyosarcoma
rhabdosarcoma
carcinosarcoma
neurosarcoma
immediately before operation
immediately before incision and post-operative for 1 day
immediately before incision and post-operative for 15 days
immediately before incision and post-operative for 30 days
undergo cystectomy
try mitomycin c
take a second course of BCG
take a second course of BCG + quinolones
continue the procedure as perforations at this site do no harm
abort the procedure and leave a urethral catheter
convert tumor removal to open method and repair the defect
perform abdominal exploration and manage accordingly
epirubicin
mitomycin c
BCG
none of the above
adenocarcinoma
transitional cell carcinoma
squamous cell carcinoma
basal cell carcinoma
working with organic chemicals and dyes
abuse of pain-control medications especially phenacetin
exposure to arsenic and aromatic amines
schistosomiasis