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Current Affairs January 2024

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4

What is false concerning antiretroviral medications?

A. multiple antiretroviral drugs can be combined into a single pill

B. might cause radiolucent renal stones

C. can lead to a significant rise in the serum level of PDE5 inhibitors, if taken simultaneously

D. have the advantage of structured treatment interruptions (drug holidays)

Correct Answer :

D. have the advantage of structured treatment interruptions (drug holidays)


drug holidays (or structured treatment interruptions) are intentional discontinuations of antiretroviral drug treatment. Studies have shown that this regimen carries higher rates of opportunistic infections, cancers, heart attacks and death.

Related Questions

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4

What is the most common serotype of HPV associated with squamous cell carcinoma of the penis?

A. 16

B. 18

C. 22

D. 12

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4

Which statement best defines reinfection?

A. a new episode of UTI caused by different species or occurring at long intervals

B. recurrent UTIs caused by the same organism in each instance, classically, at close intervals

C. recurrent UTIs due to failure of medical therapy to eradicate the infection

D. recurrent UTIs due to a persistent pathology that is obstinate to surgery

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4

Which of the following conditions does NOT cause bacterial persistence?

A. perivesical abscess with fistula to bladder

B. acute tubular necrosis

C. renal papillary necrosis

D. xanthogranulomatous pyelonephritis

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4

What is false concerning the management of genitourinary TB?

A. prostatic TB is better drained per rectum before initiating the medications

B. renal TB may require nephroureterectomy

C. peripheral neuritis is a known side effect of isoniazid

D. moxifloxacin might result in tendon rupture

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4

In which segmented voided bladder (VB) specimen, the diagnosis of chronic prostatitis is confirmed?

A. VB1 and VB3

B. prostatic secretions and the VB3

C. prostatic secretions and the VB2

D. prostatic secretions and the VB1

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4

What is true regarding acute pyelonephritis?

A. a cause of obstruction should be sought

B. PCN is placed to decompress the kidney and preserve renal function

C. blood-born staphylococci are commoner than ascending E.coli infections

D. blood and urine cultures must dictate the antibiotic choice from day 1

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4

What is the commonest intra-scrotal pathology in AIDS patients?

A. beaded vas deferens

B. testicular micrilithiasis

C. testicular atrophy

D. epididymal granuloma

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4

What is false concerning acute pyelonephritis?

A. CBC reveals leucocytosis with predominance of neutrophils

B. contrast CT reveals one or more focal wedge-like swollen regions of the kidney parenchyma, sparing the cortex, and demonstrating reduced enhancement rim sign

C. in children, recurrent acute pyelonephritis might lead to renal scarring

D. in pregnancy, recurrent acute pyelonephritis might lead to preterm labor

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4

A 40 yrs. man presents with clinical acute pyelonephritis, on intravenous antibiotics for 4 days, CT shows a renal abscess. What is next in the treatment?

A. carry on the full antibiotic course, and then repeat CT

B. incision and drainage of the renal abscess with/without nephrectomy

C. the abscess size dictates management

D. perc. drainage of the renal abscess

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4

What kind of non-infectious cystitis, do patients with systemic lupus erythematosus (SLE), likely to develop?

A. cystitis glandularis

B. cystitis cystica

C. esinophilic cystitis

D. cystitis follicularis

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4

What is (are) the prominent clinical finding(s) in the diagnosis of acute pyelonephritis?

A. fever, chills, abdominal pain

B. costovertibral angle tenderness

C. hypogastric and loin pain

D. flank pain, dysuria

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4

What is false concerning epididymitis?

A. should be distinguished from testicular torsion in the emergency setting

B. viral epididymitis is commoner in the elderly

C. chronic epididymitis might complicate BPH

D. chronic epididymitis might require epididymectomy

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4

Directed physiotherapy could be of value in treating what NIH type of prostatitis?

A. type II

B. type III-a

C. type III-b

D. type IV

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4

What is true concerning scrotal abscesses?

A. could be a complication of chronic epididymitis and orchalgia

B. testicular torsion must be excluded

C. infected hair follicles and scrotal lacerations are predisposing factors

D. urethral discharge is not uncommon presentation

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4

When comparing nosocomial to community-acquired UTI, the latter is:

A. 45% are caused by E. coli

B. related to an indwelling urinary catheter in approximately 40% of cases

C. responds fairly to oral antibiotics

D. tends to report higher antibiotic resistance

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4

Which of the following does NOT cause unresolved bacteriuria?

A. giant staghorn stone

B. perivesical abscess with fistula to the bladder

C. bacterial resistance

D. self-inflicted infection

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4

Histologically, the pathognomonic finding of Fournier gangrene include:

A. necrosis of the superficial and deep fascial planes

B. fibrinoid thrombosis of the nutrient arterioles

C. polymorphonuclear cell infiltration

D. all of the above

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4

What is false regarding biopsy-taking from interstitial cystitis bladder?

A. no pathognomonic histology for interstitial cystitis

B. basically, biopsies are performed to exclude carcinomas and other varieties of cystitis

C. diagnostic biopsies include the presence of discrete micro-ulcers and increased numbers of mast cells in the detrusor muscle or submucosa

D. none of the above

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4

What is false concerning HIV infection?

A. AIDS patients in active infection show low CD4 + T-cell count

B. the diagnosis is confirmed by positive anti-HIV-1, anti-HIV-2 antibodies

C. patients receiving antiviral therapy could still be infectious

D. herpes simplex virus increases HIV replication in infected persons

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4

What type of cells is implicated most in the pathogenesis of BPS/IC?

A. histocytes

B. T lymphocytes

C. mast cells

D. B lymphocytes

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4

What is true regarding honeymoon cystitis?

A. is a self-limiting infection where antibiotics are not required

B. is exclusively for UTI experienced by a girl after sexual intercourse on her wedding night

C. post-coital voiding has no value in the occurrence of the infection

D. self-initiated medication helps control the infection

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4

What is false regarding cystitis cystica?

A. most cysts appear as filling defects on cystography

B. most often found in the trigone area

C. the cyst lumens contain esinophilic secretions that may have a few inflammatory cells

D. cystitis cystica and cystitis glandularis are reactive urothelial changes

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4

What is true regarding balanoposthitis?

A. is best diagnosed by ascending urethrography

B. occurs mostly in diabetic and immunosuppressed patients

C. could be due to maceration injury, irritant dermatitis, or Candida

D. commonly presents with deep inguinal lymphadenopathy

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4

What is the percentage of occurrence of Staphylococcus saprophyticus in symptomatic lower UTIs in young sexually active females?

A. 5%

B. 10%

C. 15%

D. 20%

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4

What is false concerning peri-renal abscess?

A. could result from intra-renal abscess of ascending infection

B. urine culture might be negative

C. plain KUB X-ray has no value in the diagnosis

D. surgical drainage is the proper treatment

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4

A 48 yrs. woman presents with recurrent cystitis. Cystoscopy showed a raised bladder lesion. Biopsies from the lesion reveals Von Hansemann histiocytes, and Michaelis-Gutmann bodies. What is the treatment?

A. sulfonamide for several months

B. TUR of the bladder lesion followed by proper staging

C. radical cystectomy and urinary diversion

D. intravesical installation of mitomycin without irradiation

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4

Which of the following factors increases the risk of UTI due to promotion of microbial colonization?

A. neurogenic bladder

B. the use of spermicide

C. urinary catheterization

D. fecal incontinence

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4

What is false concerning esinophilic cystitis?

A. probably due to antibody/antigen reaction

B. has no diagnostic findings on cystoscopy

C. has no specific medical therapy

D. on histology, Von Brunn`s nests appear invaginating the urothelium into the lamina propria

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4

What is NOT a poor clinical practice on caring for urethral catheters?

A. taking urine samples by draining the urine bag

B. daily cleansing the external meatus

C. placing the urine bag on the floor

D. changing the urine bag once it is full

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4

What is false concerning post UTI renal scarring in pediatrics?

A. the incidence of scarring following a single episode of febrile UTI is 4.5%

B. intra-renal reflux is common in convex papillae

C. scarring and chronic pyelonephritis lead to hypertension in 10-20%

D. scarring is best detected and followed up by DMSA