0.6 - 2%
2 - 6%
6 - 10%
12 - 16%
B. 2 - 6%
obesity
consuming artificial sweeteners
asbestosis
analgesic abuse
never
unlikely
likely
always
frequently found in association with high-grade or extensive TCC
has a rate of progression to muscle invasion of 10-25%
significant areas of CIS are easily missed by routine cystoscopy
treatment begins with TURBT
urine cytology
CT urography
cystoscopy
renal function tests
obstructive LUTS are common presentations and occur in association with carcinoma in situ
might present as perineal abscesses and fistulae
could be asymptomatic
venereal diseases increase the risk of urethral cancers
often of high-grade sarcomas
often associated with muscularis propria invasion
due to vesical polyps occluding ureteric orifices
should be resected but not diathermized
patients with carcinoma in situ
patients with completely resected solitary tumor
patients with preserved kidney and liver functions after 2 courses of BCG
patients with leiomyosarcoma
adenocarcinoma
transitional cell carcinoma
squamous cell carcinoma
basal cell carcinoma
high specificity
high sensitivity
high reliability
strong validity
rarely diagnosed at autopsy
the peak incidence occurs between ages 70 and 80
they occur twice as frequently in men as in women
none of the above
bladder perforation
obturator nerve reflex
vesico-ureteral reflux
terrible bleeding
epirubicin
mitomycin c
BCG
none of the above
leiomyoma
hemangioma
fibroepithelial polyp
lymphangioma
working with organic chemicals and dyes
abuse of pain-control medications especially phenacetin
exposure to arsenic and aromatic amines
schistosomiasis
2%
5%
70%
90%
irritative bladder symptoms
obstructive bladder symptoms
palpable suprapubic mass on physical examination
painless profuse hematuria
leiomyosarcoma
rhabdosarcoma
carcinosarcoma
neurosarcoma
adenocarcinoma
transitional cell carcinoma
squamous cell carcinoma
basal cell carcinoma
ascending urethrography
voiding cystourethrography
MRI
IVU
adenocarcinoma
transitional cell carcinoma
squamous cell carcinoma
basal cell carcinoma
sensitivity to chemotherapy and age at presentation
anatomic location and extent of the tumor
histologic type of the tumor and sensitivity to radiotherapy
tumors stage and grade
well-differentiated tumor with broad-based invasive font
marked atypia distributed on wide areas of superficial urothelium
atypia is present
no atypia but marked degenerative epithelial changes
40 - 55%
55 - 70%
70 - 85%
85 - 100%
10%
20%
30%
40%
single intravesical chemotherapy
TURBT
intravesical BCG vaccine
multiple bladder biopsies
the lesion is solitary and no associated CIS
physically, a surgical margin of 2-cm can be obtained
the resected area should be far enough from ureteral orifices and the bladder neck
all of the following
transitional cell carcinoma
squamous cell carcinoma
adenocarcinoma
small cell carcinoma
undergo cystectomy
try mitomycin c
take a second course of BCG
take a second course of BCG + quinolones
30%
40%
50%
60%
continue the procedure as perforations at this site do no harm
abort the procedure and leave a urethral catheter
convert tumor removal to open method and repair the defect
perform abdominal exploration and manage accordingly