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Which RCC subtype is most likely to benefit from targeted molecular therapy?

A. clear cell

B. chromophobe

C. papillary

D. renal medullary

Correct Answer :

A. clear cell


targeted molecular therapies like TKIs, chiefly target VEGF. Therefore, the pathways that are typically upregulated are in clear cell variety of RCC.

Related Questions

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On histological examination of a resected renal tumor, positive staining for human melanoma black (HMB)-45 is a distinctive and diagnostic feature for:

A. multiloculated cystic nephromas

B. angiomyolipoma

C. metanephric adenoma

D. adenoma with clear cell

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The likelihood of malignancy in category IIF (indeterminate) renal cysts is:

A. 20%

B. 30%

C. 40%

D. 50%

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4

Which of the following conditions carries the best prognosis?

A. acquired cystic renal disease

B. juvenile nephronophthisis

C. medullary sponge kidney

D. bilateral multicystic dysplastic kidney

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4

What does determine the renal function status after partial nephrectomy of a single kidney?

A. the quality of the kidney and renal function prior to surgery

B. the quantity of vascularized parenchymal mass preserved after excision

C. the tumor

D. warm ischemia time

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4

What is (are) true regarding the etiology of medullary cystic kidney disease (MCKD)?

A. mutations in the MCKD1 (chromosome 1q21) gene

B. mutations in the MCKD2 (chromosome 16q12) gene

C. inherited in an autosomal dominant fashion

D. all of the above

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4

Which of the following factors is associated with increased survival in patients with metastatic kidney tumors?

A. physically active patients with good performance status

B. extirpation of the primary tumor

C. long disease-free interval between initial nephrectomy and the emergence of secondaries

D. all of the above

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d. melanoma

A. . The second most common RCC subtype is:

B. collecting duct b. clear cell

C. papillary

D. chromophobe

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4

What is false regarding multiloculated cystic nephromas?

A. they follow a benign clinical course

B. they have a bimodal age distribution

C. they are more common in men than in women

D. none of the above

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4

The diagnosis of renal adenoma is commonly made:

A. at autopsy

B. by staining positive for human melanoma black (HMB)-45

C. by fine-needle aspiration cytology

D. by exclusion

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4

The etiology of renal cysts includes all of the following, EXCEPT:

A. autosomal dominant polycystic kidney disease (ADPKD)

B. developmental cystic renal disease

C. inherited cystic renal disease

D. systemic disease with associated renal cysts

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4

What is false concerning metanephric adenoma?

A. radiographically, it is indistinguishable from RCC

B. has a female predominance

C. has a benign clinical course

D. has a peak incidence in the third decade of life

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d. none of the above

A. . What is NOT an indication for simple nephrectomy?

B. symptomatic chronic renal infection with poor function

C. some cases of renovascular hypertension

D. symptomatic calculus disease with poor renal function

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4

What is the most common cause of genetic ESRD in children?

A. autosomal recessive polycystic kidney disease

B. autosomal dominant polycystic kidney disease

C. multicystic dysplastic kidney disease

D. juvenile nephronophthisis

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d. neurosarcoma

A. . What is false concerning targeted molecular therapy?

B. is a personalized medical therapy devised to meet each persons individual needs for cancer`s specifications

C. treats cancer by interrupting unique molecular abnormalities that drive cancer growth

D. some cancer types have different molecular targets

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4

CT shows a renal mass with calcifications associated with fat. What could the lesion be?

A. RCC

B. AML

C. teratoma

D. any of the above

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What is the likelihood that simple renal cysts increase in size and number over time?

A. never

B. unlikely

C. likely

D. always

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What is false concerning renal angiomyolipoma (AML)?

A. most lesions ≤ 4 cm are asymptomatic

B. renal masses with fat content is pathognomonic for AML

C. renal biopsy from AML carries a high risk of hemorrhage

D. may coexist with malignant lesions, such as sarcomas and RCCs

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4

What is true regarding cancer incidence in renal cystic diseases?

A. is > 90% in Bosniak type IV renal cysts

B. in patients receiving renal transplants for polycystic kidney disease is 48% higher than that expected in the general population

C. all of the above

D. simple renal cysts might turn malignant in < 4% of cases

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4

What is false concerning end-stage renal disease (ESRD)?

A. ARPKD accounts for 5% of ESRD in children

B. more than one-half of patients with ARPKD require kidney transplant before age 20 years

C. ADPKD is a common cause of ESRD

D. uncommonly, juvenile nephronophthisis causes ESRD in children

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4

Which of the following renal tumors carries the best prognosis?

A. fibrosarcoma

B. leiomyosarcoma

C. carcinoid

D. adult Wilm`s tumor

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4

On ultrasonography, what are the percentages of incidentally discovered renal masses that will later be malignant on further workup?

A. 70 - 85%

B. 55 - 70%

C. 40 - 55%

D. 25 - 40%

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4

What can NOT be a manifestation of a renal tumor?

A. right hydrocele

B. left varicocele

C. painless hematuria

D. hypertension

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4

Which RCC subtype is most likely to benefit from targeted molecular therapy?

A. clear cell

B. chromophobe

C. papillary

D. renal medullary

What is the correct answer?

4

What is true regarding ADPKD patients?

A. progress to ESRD in the sixth decade of life

B. hypertension is seen in 80% of patients with ADPKD aged 20-34 years

C. aortic valve stenosis in 25%

D. manifestations are more significant in patients with the PKD2 genotype

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4

Fuhrmans grading system for renal cell carcinoma relies on:

A. nuclear size, outline, and nucleoli

B. cohesiveness and the degree of cellular atypia

C. chromatin structure and content of the interphase nucleus

D. multinucleation and mitosis

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4

In a localized RCC, local recurrence after tumor ablation therapy is managed by any of the following options, EXCEPT:

A. repeat ablation

B. active surveillance

C. salvage surgery

D. radical nephrectomy

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d. 30 - 40%

A. . What is false concerning imaging studies for preoperative evaluation of RCC case?

B. in case of bone pain or elevated serum calcium and/or alkaline phosphatase levels, an isotopic bone scan is required

C. renal arteriography accurately localizes central scaring and tumor necrosis

D. trans-esophageal echocardiography helps assess vena caval and right atrial tumor thrombi

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4

What is the most powerful single predictor of oncologic outcomes in RCC cases?

A. margin status and grade

B. tumor size

C. tumor stage

D. the time interval between the tumor emergence and excision

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d. all of the above

A. . What is the most common histologic subtype of renal sarcomas?

B. rhabdomyosarcoma

C. nephrosarcoma

D. leiomyosarcoma

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Routine metastatic evaluation in RCC cases should include all of the following, EXCEPT:

A. abdominal CT

B. chest X-ray

C. renal function test

D. liver function test