clear cell
chromophobe
papillary
renal medullary
A. clear cell
multiloculated cystic nephromas
angiomyolipoma
metanephric adenoma
adenoma with clear cell
20%
30%
40%
50%
acquired cystic renal disease
juvenile nephronophthisis
medullary sponge kidney
bilateral multicystic dysplastic kidney
the quality of the kidney and renal function prior to surgery
the quantity of vascularized parenchymal mass preserved after excision
the tumor
warm ischemia time
mutations in the MCKD1 (chromosome 1q21) gene
mutations in the MCKD2 (chromosome 16q12) gene
inherited in an autosomal dominant fashion
all of the above
physically active patients with good performance status
extirpation of the primary tumor
long disease-free interval between initial nephrectomy and the emergence of secondaries
all of the above
. The second most common RCC subtype is:
collecting duct b. clear cell
papillary
chromophobe
they follow a benign clinical course
they have a bimodal age distribution
they are more common in men than in women
none of the above
at autopsy
by staining positive for human melanoma black (HMB)-45
by fine-needle aspiration cytology
by exclusion
autosomal dominant polycystic kidney disease (ADPKD)
developmental cystic renal disease
inherited cystic renal disease
systemic disease with associated renal cysts
radiographically, it is indistinguishable from RCC
has a female predominance
has a benign clinical course
has a peak incidence in the third decade of life
. What is NOT an indication for simple nephrectomy?
symptomatic chronic renal infection with poor function
some cases of renovascular hypertension
symptomatic calculus disease with poor renal function
autosomal recessive polycystic kidney disease
autosomal dominant polycystic kidney disease
multicystic dysplastic kidney disease
juvenile nephronophthisis
. What is false concerning targeted molecular therapy?
is a personalized medical therapy devised to meet each persons individual needs for cancer`s specifications
treats cancer by interrupting unique molecular abnormalities that drive cancer growth
some cancer types have different molecular targets
RCC
AML
teratoma
any of the above
never
unlikely
likely
always
most lesions ≤ 4 cm are asymptomatic
renal masses with fat content is pathognomonic for AML
renal biopsy from AML carries a high risk of hemorrhage
may coexist with malignant lesions, such as sarcomas and RCCs
is > 90% in Bosniak type IV renal cysts
in patients receiving renal transplants for polycystic kidney disease is 48% higher than that expected in the general population
all of the above
simple renal cysts might turn malignant in < 4% of cases
ARPKD accounts for 5% of ESRD in children
more than one-half of patients with ARPKD require kidney transplant before age 20 years
ADPKD is a common cause of ESRD
uncommonly, juvenile nephronophthisis causes ESRD in children
fibrosarcoma
leiomyosarcoma
carcinoid
adult Wilm`s tumor
70 - 85%
55 - 70%
40 - 55%
25 - 40%
right hydrocele
left varicocele
painless hematuria
hypertension
clear cell
chromophobe
papillary
renal medullary
progress to ESRD in the sixth decade of life
hypertension is seen in 80% of patients with ADPKD aged 20-34 years
aortic valve stenosis in 25%
manifestations are more significant in patients with the PKD2 genotype
nuclear size, outline, and nucleoli
cohesiveness and the degree of cellular atypia
chromatin structure and content of the interphase nucleus
multinucleation and mitosis
repeat ablation
active surveillance
salvage surgery
radical nephrectomy
. What is false concerning imaging studies for preoperative evaluation of RCC case?
in case of bone pain or elevated serum calcium and/or alkaline phosphatase levels, an isotopic bone scan is required
renal arteriography accurately localizes central scaring and tumor necrosis
trans-esophageal echocardiography helps assess vena caval and right atrial tumor thrombi
margin status and grade
tumor size
tumor stage
the time interval between the tumor emergence and excision
. What is the most common histologic subtype of renal sarcomas?
rhabdomyosarcoma
nephrosarcoma
leiomyosarcoma
abdominal CT
chest X-ray
renal function test
liver function test