According to Fuhrmans classification system for nuclear grading in RCC, nuclear size of 20 μg with irregular outline and prominent nucleoli is grade:
1
2
3
4
Correct Answer :
C. 3
self-explanatory.
Related Questions
What type of renal adenomas is a precursor to papillary RCC?
adenoma with clear cell
papillary adenoma
metanephric adenoma
none of the above
On histological examination of a resected renal tumor, positive staining for human melanoma black (HMB)-45 is a distinctive and diagnostic feature for:
multiloculated cystic nephromas
angiomyolipoma
metanephric adenoma
adenoma with clear cell
In a localized RCC, local recurrence after tumor ablation therapy is managed by any of the following options, EXCEPT:
repeat ablation
active surveillance
salvage surgery
radical nephrectomy
Routine metastatic evaluation in RCC cases should include all of the following, EXCEPT:
abdominal CT
chest X-ray
renal function test
liver function test
What is the likelihood that Bosniak type III renal cysts accompany malignant masses?
never
unlikely
likely
always
What is (are) true regarding the etiology of medullary cystic kidney disease (MCKD)?
mutations in the MCKD1 (chromosome 1q21) gene
mutations in the MCKD2 (chromosome 16q12) gene
inherited in an autosomal dominant fashion
all of the above
d. hypertension
. Metastatic tumors to the kidney are common from all of the following organs, EXCEPT:
lungs
thyroid
breasts
What is the treatment of a 3-cm renal mass suggestive of RCC adjacent to a huge renal cyst?
cyst aspiration and sclerosis
partial nephrectomy
endoscopic marsupialization and fulguration of the cyst
administration of TKIs
d. renal vein thrombi can be resected after incising the vein between 2 vascular clamps
. Manifestations of paraneoplastic syndrome associated with RCC include all of the following, EXCEPT:
anemia and erythrocytosis
hepatic dysfunction and elevated human chorionic gonadotropin levels
hypocalcemia
What is false regarding multiloculated cystic nephromas?
they follow a benign clinical course
they have a bimodal age distribution
they are more common in men than in women
none of the above
What is false concerning metanephric adenoma?
radiographically, it is indistinguishable from RCC
has a female predominance
has a benign clinical course
has a peak incidence in the third decade of life
On histological examination of a resected renal tumor, the presence of multiple mitochondria observed on electron microscopy is diagnostic for:
renal oncocytoma
multiloculated cystic nephromas
metanephric adenoma
adenoma with clear cell
Which of the following is NOT a risk factor for RCC?
type II DM, especially in males
hypertension
obesity, especially in females
cigarette smoking
d. neurosarcoma
. What is false concerning targeted molecular therapy?
is a personalized medical therapy devised to meet each persons individual needs for cancer`s specifications
treats cancer by interrupting unique molecular abnormalities that drive cancer growth
some cancer types have different molecular targets
What is the most powerful single predictor of oncologic outcomes in RCC cases?
margin status and grade
tumor size
tumor stage
the time interval between the tumor emergence and excision
What is false concerning ADPKD patients?
hepatic cysts are the most common extra-renal manifestation
might experience cyst hemorrhage, renal infection, or nephrolithiasis
typically, complain of flank pain or intermittent hematuria in the early twenties
hypertension and CRF commonly occur in the fifth decade of life
d. 19 - 26%
. What is false regarding radical nephrectomy operation?
nodal involvement doesn`t influence prognosis
renal artery should be ligated before the vein to avoid kidney ballooning
cardiopulmonary bypass with deep hypothermic circulatory arrest is performed in patients with supra-diaphragmatic tumor thrombi
What does determine the renal function status after partial nephrectomy of a single kidney?
the quality of the kidney and renal function prior to surgery
the quantity of vascularized parenchymal mass preserved after excision
the tumor
warm ischemia time
What is false concerning renal angiomyolipoma (AML)?
most lesions ≤ 4 cm are asymptomatic
renal masses with fat content is pathognomonic for AML
renal biopsy from AML carries a high risk of hemorrhage
may coexist with malignant lesions, such as sarcomas and RCCs
Inherited renal cystic disease(s) include(s) the following:
glomerulocystic kidney disease (GCKD)
Juvenile nephronophthisis (JNPHP)
medullary cystic kidney disease
all of the above
The likelihood of malignancy in category IIF (indeterminate) renal cysts is:
20%
30%
40%
50%
What can NOT be a manifestation of a renal tumor?
right hydrocele
left varicocele
painless hematuria
hypertension
What is the proper terminology of a renal cyst with the following characteristics: well-marginated, anechoic, with thin visible back wall, positive posterior acoustic enhancement, no septations, and no calcifications?
hyperattenuating renal cyst
solitary renal cyst
uncomplicated renal cyst
focal renal cyst
After radical nephrectomy for organ-confined RCC, what is (are) the recommended surveillance radiologic examination(s)?
chest X-ray and abdominal ultrasonography every 3 months for the first year, and then annually for 3 years
annual chest X-ray for 3 years
abdominal and chest CT every 6 months for the first year, and then annually for 3 years
no radiological examination required
d. CT can detect renal vein involvement in 82-95% of cases and vena caval involvement in 95-100% of cases
. In RCC, ipsilateral adrenal metastasis occurs in:
0.3 - 2%
2 - 10%
11 - 18%
The diagnosis of renal adenoma is commonly made:
at autopsy
by staining positive for human melanoma black (HMB)-45
by fine-needle aspiration cytology
by exclusion
In renal mass(es), the main indication to take a renal biopsy is the suspicion of:
papillary RCC
renal metastases
renal oncocytoma
renal xanthogranuloma
What is true regarding ADPKD patients?
progress to ESRD in the sixth decade of life
hypertension is seen in 80% of patients with ADPKD aged 20-34 years
aortic valve stenosis in 25%
manifestations are more significant in patients with the PKD2 genotype
On ultrasonography, what are the percentages of incidentally discovered renal masses that will later be malignant on further workup?
70 - 85%
55 - 70%
40 - 55%
25 - 40%
What is false concerning renal cancers?
papillary subtype of RCC has a tendency to multifocality
chromosome 13 alterations are common in the development of clear cell renal carcinoma
a solid mass on CT that enhances more than 15 HU is suggestive of RCC
bilateral involvement in RCC either synchronously or metachronously occurs in 2% to 4% of patients