What is false concerning renal malignancy?
RCC occurs in < 5% of patients with tuberous sclerosis
in glomerulocystic kidney disease, renal tumors are typically solitary, large, with central necrosis
in Von Hippel-Lindau syndrome, renal tumors are frequently bilateral and multicentric
in acquired cystic disease, tumors are commonly bilateral, and metastatic in 15% of cases
Correct Answer :
B. in glomerulocystic kidney disease, renal tumors are typically solitary, large, with central necrosis
GCKD is a rare disease that doesnt cause solitary, large renal tumors, with central necrosis.
Related Questions
Which RCC subtype is most likely to benefit from targeted molecular therapy?
clear cell
chromophobe
papillary
renal medullary
What type of Bosniak renal cysts accompanies tumor masses in 5% of cases?
I
II
III
IV
Regarding simple renal cysts, fluid attenuation on non-contrast CT series is:
< - 10 HU
< - 20 HU
< 10 HU
< 20 HU
What is true regarding renal angiomyolipoma (AML)?
most classic AMLs eventually undergo malignant transformation to sarcomatoid and epithelioid AML
the preferred treatment is nephroureterectomy followed by active surveillance
angiographic embolization and/or nephron-sparing surgery is advised for symptomatic AMLs greater than 4 cm
extra-renal sites include the pancreas, salivary glands, and thyroids
On histological examination of a resected renal tumor, positive staining for human melanoma black (HMB)-45 is a distinctive and diagnostic feature for:
multiloculated cystic nephromas
angiomyolipoma
metanephric adenoma
adenoma with clear cell
Which of the following factors is associated with increased survival in patients with metastatic kidney tumors?
physically active patients with good performance status
extirpation of the primary tumor
long disease-free interval between initial nephrectomy and the emergence of secondaries
all of the above
Which of the following conditions carries the worst prognosis?
acquired cystic renal disease
juvenile nephronophthisis
medullary sponge kidney
bilateral multicystic dysplastic kidney
Antenatal sonography is the diagnostic tool for the following condition:
glomerulocystic kidney disease
developmental cystic renal disease
Juvenile nephronophthisis
medullary cystic kidney disease
d. hypertension
. Metastatic tumors to the kidney are common from all of the following organs, EXCEPT:
lungs
thyroid
breasts
Which of the following conditions carries the best prognosis?
acquired cystic renal disease
juvenile nephronophthisis
medullary sponge kidney
bilateral multicystic dysplastic kidney
d. 19 - 26%
. What is false regarding radical nephrectomy operation?
nodal involvement doesn`t influence prognosis
renal artery should be ligated before the vein to avoid kidney ballooning
cardiopulmonary bypass with deep hypothermic circulatory arrest is performed in patients with supra-diaphragmatic tumor thrombi
What does determine the renal function status after partial nephrectomy of a single kidney?
the quality of the kidney and renal function prior to surgery
the quantity of vascularized parenchymal mass preserved after excision
the tumor
warm ischemia time
d. prior to kidney transplant
. What is an indication for radical nephrectomy?
a 6-cm, polar tumor
bilateral RCC
locally advanced RCC
On histological examination of a resected renal tumor, the presence of multiple mitochondria observed on electron microscopy is diagnostic for:
renal oncocytoma
multiloculated cystic nephromas
metanephric adenoma
adenoma with clear cell
What is the most powerful single predictor of oncologic outcomes in RCC cases?
margin status and grade
tumor size
tumor stage
the time interval between the tumor emergence and excision
Which of the following renal tumors carries the best prognosis?
fibrosarcoma
leiomyosarcoma
carcinoid
adult Wilm`s tumor
After radical nephrectomy for organ-confined RCC, what is (are) the recommended surveillance radiologic examination(s)?
chest X-ray and abdominal ultrasonography every 3 months for the first year, and then annually for 3 years
annual chest X-ray for 3 years
abdominal and chest CT every 6 months for the first year, and then annually for 3 years
no radiological examination required
Which of the following is NOT a risk factor for RCC?
type II DM, especially in males
hypertension
obesity, especially in females
cigarette smoking
The likelihood of malignancy in category IIF (indeterminate) renal cysts is:
20%
30%
40%
50%
d. CT can detect renal vein involvement in 82-95% of cases and vena caval involvement in 95-100% of cases
. In RCC, ipsilateral adrenal metastasis occurs in:
0.3 - 2%
2 - 10%
11 - 18%
What is the likelihood that Bosniak type III renal cysts accompany malignant masses?
never
unlikely
likely
always
What is false concerning metanephric adenoma?
radiographically, it is indistinguishable from RCC
has a female predominance
has a benign clinical course
has a peak incidence in the third decade of life
d. 30 - 40%
. What is false concerning imaging studies for preoperative evaluation of RCC case?
in case of bone pain or elevated serum calcium and/or alkaline phosphatase levels, an isotopic bone scan is required
renal arteriography accurately localizes central scaring and tumor necrosis
trans-esophageal echocardiography helps assess vena caval and right atrial tumor thrombi
What is false concerning end-stage renal disease (ESRD)?
ARPKD accounts for 5% of ESRD in children
more than one-half of patients with ARPKD require kidney transplant before age 20 years
ADPKD is a common cause of ESRD
uncommonly, juvenile nephronophthisis causes ESRD in children
What is (are) true regarding the etiology of medullary cystic kidney disease (MCKD)?
mutations in the MCKD1 (chromosome 1q21) gene
mutations in the MCKD2 (chromosome 16q12) gene
inherited in an autosomal dominant fashion
all of the above
The etiology of renal cysts includes all of the following, EXCEPT:
autosomal dominant polycystic kidney disease (ADPKD)
developmental cystic renal disease
inherited cystic renal disease
systemic disease with associated renal cysts
What is false concerning ADPKD patients?
hepatic cysts are the most common extra-renal manifestation
might experience cyst hemorrhage, renal infection, or nephrolithiasis
typically, complain of flank pain or intermittent hematuria in the early twenties
hypertension and CRF commonly occur in the fifth decade of life
Inherited renal cystic disease(s) include(s) the following:
glomerulocystic kidney disease (GCKD)
Juvenile nephronophthisis (JNPHP)
medullary cystic kidney disease
all of the above
The diagnosis of renal adenoma is commonly made:
at autopsy
by staining positive for human melanoma black (HMB)-45
by fine-needle aspiration cytology
by exclusion
Fuhrmans grading system for renal cell carcinoma relies on:
nuclear size, outline, and nucleoli
cohesiveness and the degree of cellular atypia
chromatin structure and content of the interphase nucleus
multinucleation and mitosis